Table 2.
The major targets of ginger for colon cancer treatment and the topological parameters
| Uniprot ID | Gene symbol | Target name | Degree | Betweenness | Closeness |
|---|---|---|---|---|---|
| P42336 | PIK3CA | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 42 | 0.187322 | 0.572254 |
| P12931 | SRC | Proto-oncogene tyrosine-protein kinase | 38 | 0.107991 | 0.568966 |
| P27986 | PIK3R1 | Phosphatidylinositol 3-kinase regulatory subunit alpha | 38 | 0.106891 | 0.568966 |
| P04637 | TP53 | Cellular tumor antigen p53 | 35 | 0.103695 | 0.546961 |
| P27361 | MAPK3 | Mitogen-activated protein kinase 3 | 33 | 0.084312 | 0.543956 |
| P40763 | STAT3 | Signal transducer and activator of transcription 3 | 31 | 0.080670 | 0.535135 |
| P31749 | AKT1 | RAC-alpha serine/threonine-protein kinase | 29 | 0.068649 | 0.532258 |
| P07900 | HSP90AA1 | Heat shock protein HSP 90-alpha | 27 | 0.066522 | 0.529412 |
| P45983 | MAPK8 | Mitogen-activated protein kinase 8 | 23 | 0.065784 | 0.502538 |
| O60674 | JAK2 | Tyrosine-protein kinase JAK2 | 20 | 0.056021 | 0.497487 |
| P42338 | PIK3CB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform | 19 | 0.036367 | 0.492537 |
| P00533 | EGFR | Epidermal growth factor receptor | 19 | 0.028652 | 0.485294 |
| Q05513 | PRKCZ | Protein kinase C zeta type | 18 | 0.021649 | 0.480583 |
| Q05655 | PRKCD | Protein kinase C delta type | 18 | 0.021286 | 0.478261 |
| P23458 | JAK1 | Tyrosine-protein kinase JAK1 | 18 | 0.017349 | 0.478261 |
| P03372 | ESR1 | Estrogen receptor | 18 | 0.016778 | 0.473684 |
| Q04206 | RELA | Transcription factor p65 | 17 | 0.014046 | 0.469194 |
| Q16539 | MAPK14 | Mitogen-activated protein kinase 14 | 17 | 0.011251 | 0.469194 |
| Q05397 | PTK2 | Focal adhesion kinase 1 | 15 | 0.009972 | 0.464789 |
| Q02750 | MAP 2 K1 | Dual specificity mitogen-activated protein kinase kinase 1 | 15 | 0.009205 | 0.464789 |
| P04626 | ERBB2 | Receptor tyrosine-protein kinase erbB-2 | 15 | 0.008965 | 0.464789 |
| P42574 | CASP3 | Caspase-3 | 15 | 0.008693 | 0.462617 |
| P04150 | NR3C1 | Glucocorticoid receptor | 14 | 0.00863 | 0.460465 |
| P05412 | JUN | Transcription factor AP-1 | 14 | 0.008501 | 0.458333 |
| P52333 | JAK3 | Tyrosine-protein kinase JAK3 | 14 | 0.008096 | 0.450000 |
| P06493 | CDK1 | Cyclin-dependent kinase 1 | 14 | 0.007042 | 0.450000 |
| P17252 | PRKCA | Protein kinase C alpha type | 13 | 0.006885 | 0.447964 |
| P10275 | AR | Androgen receptor | 13 | 0.005944 | 0.445946 |
| P08069 | IGF1R | Insulin-like growth factor I receptor | 11 | 0.005841 | 0.443946 |
| O14965 | AURKA | Aurora kinase A | 11 | 0.005668 | 0.440000 |
| P00519 | ABL1 | Tyrosine-protein kinase ABL1 | 11 | 0.005616 | 0.432314 |
| Q00987 | MDM2 | E3 ubiquitin-protein ligase Mdm2 | 10 | 0.00552 | 0.415966 |
| P24941 | CDK2 | Cyclin-dependent kinase 2 | 10 | 0.004538 | 0.415966 |
| P49841 | GSK3B | Glycogen synthase kinase-3 beta | 8 | 0.004458 | 0.415966 |