Table 2.

Associations of baseline glomerular filtration rate (GFR_crcys) estimated by the CKD-EPI equations with incidence of dementia and Alzheimer’s disease

	Dementia				Alzheimer’s disease
	Unadjusted		Adjusted		Unadjusted		Adjusted
	HR (95% CI)	P	HR (95% CI)	Pa	HR (95% CI)	P	HR (95% CI)	Pa
All participants
Tertile of GFRcrcys
GFRcrcys > 80 ml/min/1.73 m2	Ref		Ref		Ref		Ref
67 ≤ GFRcrcys < 80 ml/min/1.73 m2	2.77 (1.53 to 5.05)	0.001	1.87 (1.02 to 3.44)	0.04	3.60 (1.77 to 7.32)	< 0.001	2.27 (1.10 to 4.68)	0.03
GFRcrcys < 67 ml/min/1.73 m2	4.90 (2.79 to 8.63)	< 0.001	2.19 (1.21 to 3.95)	0.009	5.06 (2.54 to 10.10)	< 0.001	2.14 (1.04 to 4.40)	0.04
Participants without stroke history
Tertile of GFRcrcys
GFRcrcys > 80 ml/min/1.73 m2	Ref		Ref		Ref		Ref
67 ≤ GFRcrcys < 80 ml/min/1.73 m2	2.71 (1.38 to 5.33)	0.004	1.78 (0.89 to 3.55)	0.10	3.99 (1.72 to 9.26)	0.001	2.47 (1.05 to 5.86)	0.04
GFRcrcys < 67 ml/min/1.73 m2	4.59 (2.42 to 8.71)	< 0.001	2.19 (1.12 to 4.29)	0.02	6.03 (2.67 to 13.64)	< 0.001	2.80 (1.19 to 6.58)	0.02

GFR_crcys glomerular filtration rate estimated by the CKD-EPI creatinine–cystatin C equation, HR hazard ratio, CI confidence interval

^aP adjusted for age, gender, education years, APOE-ε4 positive, diabetes, hypertension, mini-mental state examination (MMSE), and proteinuria (positive, negative)