Table 4:
Results from the Cox regression analysis for OS and DFS according to 7th and 8th TNM classifications.
| OS based on 7th TNM | DFS based on 7th TNM | ||||||
|---|---|---|---|---|---|---|---|
| Variable | p-Value | HR | 95% CI | Variable | p-Value | HR | 95% CI |
| Gender | Gender | ||||||
| Male | Reference | Male | Reference | ||||
| Female | <0.001 | 0.79 | 0.72–0.87 | Female | <0.001 | 0.86 | 0.79–0.93 |
| Age | Age | ||||||
| ≤65 years | Reference | ≤65 years | Reference | ||||
| >65 years | <0.001 | 1.22 | 1.11–1.33 | >65 years | <0.001 | 1.20 | 1.11–1.30 |
| Surgery | Surgery | ||||||
| (Bi-)lobectomy | Reference | (Bi-)lobectomy | Reference | ||||
| Pneumonectomy | <0.001 | 0.66 | 0.51–0.86 | Pneumonectomy | <0.001 | 0.67 | 0.53–0.86 |
| Segmentectomy | <0.001 | 1.30 | 1.01–1.58 | Segmentectomy | 0.116 | 1.19 | 0.96–1.48 |
| Wedge resection | <0.001 | 1.52 | 1.17–1.98 | Wedge resection | <0.001 | 1.58 | 1.24–2.02 |
| UICC 7 | UICC 7 | ||||||
| Stage IA | Reference | Stage IA | Reference | ||||
| Stage IB | <0.001 | 0.68 | 0.55–0.83 | Stage IB | <0.001 | 0.69 | 0.57–0.84 |
| Stage IIA | <0.001 | 0.67 | 0.53–0.84 | Stage IIA | <0.001 | 0.68 | 0.56–0.83 |
| Stage IIB | 0.29 | 0.89 | 0.72–1.10 | Stage IIB | 0.628 | 0.95 | 0.78–1.16 |
| Stage IIIA | <0.001 | 1.62 | 1.38–1.92 | Stage IIIA | <0.001 | 1.53 | 1.31–1.79 |
| Stage IIIB | <0.001 | 2.53 | 1.75–3.67 | Stage IIIB | <0.001 | 2.20 | 1.52–3.16 |
| OS based on 8th TNM | DFS based on 8th TNM | ||||||
| Gender | Gender | ||||||
| Male | Reference | Male | Reference | ||||
| Female | <0.001 | 0.80 | 0.73–0.88 | Female | <0.001 | 0.86 | 0.79–0.93 |
| Age | Age | ||||||
| ≤65 years | Reference | ≤65 years | Reference | ||||
| >65 years | <0.001 | 1.21 | 1.11–1.33 | >65 years | <0.001 | 1.19 | 1.1–1.3 |
| Surgery | Surgery | ||||||
| (Bi-)lobectomy | Reference | (Bi-)lobectomy | Reference | ||||
| Pneumonectomy | <0.001 | 0.62 | 0.48–0.80 | Pneumonectomy | <0.001 | 0.63 | 0.49–0.81 |
| Segmentectomy | 0.013 | 1.34 | 1.06–1.69 | Segmentectomy | 0.04 | 1.26 | 1.01–1.57 |
| Wedge resection | <0.001 | 1.63 | 1.25–2.11 | Wedge resection | <0.001 | 1.65 | 1.30–2.10 |
| UICC 8 | UICC 8 | ||||||
| Stage IA1 | Reference | Stage IA1 | Reference | ||||
| Stage IA2 | 0.08 | 0.81 | 0.64–1.03 | Stage IA2 | 0.04 | 0.81 | 0.66– 0.99 |
| Stage IA3 | 0.21 | 0.84 | 0.64–1.11 | Stage IA3 | 0.31 | 0.88 | 0.70–1.12 |
| Stage IB | 0.07 | 0.78 | 0.59–1.02 | Stage IB | 0.04 | 0.78 | 0.61–0.99 |
| Stage IIA | 0.95 | 0.99 | 0.75–1.32 | Stage IIA | 0.68 | 0.95 | 0.74–1.22 |
| Stage IIB | 0.29 | 0.89 | 0.71–1.11 | Stage IIB | 0.20 | 0.88 | 0.72–1.07 |
| Stage IIIA | <0.001 | 1.66 | 1.39–1.99 | Stage IIIA | <0.001 | 1.53 | 1.30–1.80 |
| Stage IIIB | <0.001 | 3.05 | 2.41–3.87 | Stage IIIB | <0.001 | 2.59 | 2.06–3.26 |
OS = overall survival, DFS = disease free survival, CI = confidence interval; HR = hazard ratio; UICC = Union for Inter-national Cancer Control.