Table 5:

Comparison of neighboring Union for International Cancer Control (UICC) stages: Cox regression analysis after adjusting for gender, surgery, and age.

OS based on 7th edition TNM
Stage	p-Value	HR	95% CI
IA vs. IB	<0.001	0.61	0.51–0.73
IB vs. IIA	<0.001	0.41	0.31–0.54
IIA vs. IIB	<0.001	0.27	0.20–0.38
IIB vs. IIIA	<0.001	0.24	0.17–0.34
IIIA vs. IIIB	<0.001	0.39	0.27–0.57
OS based on 8th edition TNM
IA1 vs. 1A2	0.004	0.42	0.24–0.75
IA2 vs. IA3	<0.001	0.34	0.20–0.59
IA3 vs. IB	<0.001	0.29	0.17–0.48
IB vs. IIA	<0.001	0.22	0.14–0.36
IIA vs. IIB	<0.001	0.22	0.15–0.33
IIB vs. IIIA	<0.001	0.20	0.14–0.27
IIIA vs. IIIB	<0.001	0.33	0.26–0.42
DFS based on 7th edition TNM
IA vs. IB	<0.001	0.66	0.56–0.78
IB vs. IIA	<0.001	0.46	0.36–0.59
IIA vs. IIB	<0.001	0.31	0.23–0.42
IIB vs. IIIA	<0.001	0.30	0.21–0.42
IIIA vs. IIIB	<0.001	0.46	0.32–0.66
DFS based on 8th edition TNM
IA1 vs. 1A2	0.015	0.55	0.34–0.89
IA2 vs. IA3	<0.001	0.44	0.28–0.70
IA3 vs. IB	<0.001	0.39	0.25–0.61
IB vs. IIA	<0.001	0.30	0.20–0.46
IIA vs. IIB	<0.001	0.29	0.20–0.41
IIB vs. IIIA	<0.001	0.25	0.19–0.34
IIIA vs. IIIB	<0.001	0.39	0.31–0.48

OS = overall survival; DFS = disease free survival; HR = hazard ratio; CI = confidence interval.