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. 2021 Jan 11;21:48. doi: 10.1186/s12885-020-07717-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of miRNA-486-5p restoration on cell proliferation, migration, invasion and apoptosis in CDDP-R-BC cell lines. a Expression levels of miRNA-486-5p determined by qRT-PCR were significantly lower in cisplatin-resistant BC cell lines than in parental BC cell lines. *, P < 0.05. b Cell proliferation determined by XTT assay. *, P < 0.01; * *, P < 0.001. c Cell migration activity determined with wound healing assay. *, P < 0.01; * *, P < 0.001. d Cell invasion activity determined with Matrigel invasion assay. *, P < 0.001. e Western blot analysis of apoptotic markers (cleaved PARP and PARP) in CDDP-R-BOY and CDDP-R-T24. The full-length blots/gels are presented in Supplementary Figure 8.