Figure 2. Distribution of mutations in samples and their biological effects. The figure was constructed using the OncoPrinter from cBioPortal for Cancer Genomics database (http://www.cbioportal.org/). Each gray rectangle represents a sample according to the sequence indicated at the top. Genes with the highest frequency of alterations are shown. Captions for each type of alteration (Loss of function - Black Square; Missense - Green Square; Two alterations in the same gene - vertical line [modified by authors]; No alteration - gray rectangle) are indicated.