Table S1. Ion AmpliSeq Comprehensive Cancer Panel target gene list.

1	ABL1	CBL	EP300	GATA2	LAMP1	MYD88	PKHD1	SMARCA4	WHSC1
2	ABL2	CCND1	EP400	GATA3	LCK	MYH11	PLAG1	SMARCB1	WRN
3	ACVR2A	CCND2	EPHA3	GDNF	LIFR	MYH9	PLCG1	SMO	WT1
4	ADAMTS20	CCNE1	EPHA7	GNA11	LPHN3	NBN	PLEKHG5	SMUG1	XPA
5	AFF1	CD79A	EPHB1	GNAQ	POT1	NCOA1	PML	SOCS1	XPC
6	AFF3	CD79B	EPHB4	GNAS	LPP	NCOA2	PMS1	SOX11	XPO1
7	AKAP9	CDC73	EPHB6	GPR124	LRP1B	NCOA4	PMS2	SOX2	XRCC2
8	AKT1	CDH1	ERBB2	GRM8	LTF	NF1	POU5F1	SRC	ZNF384
9	AKT2	CDH11	ERBB3	GUCY1A2	LTK	NF2	PPARG	SSX1	ZNF521
10	AKT3	CDH2	ERBB4	HCAR1	MAF	NFE2L2	PPP2R1A	STK11
11	ALK	CDH20	ERCC1	HIF1A	MAFB	NFKB1	PRDM1	STK36
12	APC	CDH5	ERCC2	HLF	MAGEA1	NFKB2	PRKAR1A	SUFU
13	AR	CDK12	ERCC3	HNF1A	MAGI1	NIN	PRKDC	SYK
14	ARID1A	CDK4	ERCC4	HOOK3	MALT1	NKX2-1	PSIP1	SYNE1
15	ARID2	CDK6	ERCC5	HRAS	MAML2	NLRP1	PTCH1	TAF1
16	ARNT	CDK8	ERG	HSP90AA1	MAP2K1	NOTCH1	PTEN	TAF1L
17	ASXL1	CDKN2A	ESR1	HSP90AB1	MAP2K2	NOTCH2	PTGS2	TAL1
18	ATF1	CDKN2B	ETS1	ICK	MAP2K4	NOTCH4	PTPN11	TBX22
19	ATM	CDKN2C	ETV1	IDH1	MAP3K7	NPM1	PTPRD	TCF12
20	ATR	CEBPA	ETV4	IDH2	MAPK1	NRAS	PTPRT	TCF3
21	ATRX	CHEK1	EXT1	IGF1R	MAPK8	NSD1	RAD50	TCF7L1
22	AURKA	CHEK2	EXT2	IGF2	MARK1	NTRK1	RAF1	TCF7L2
23	AURKB	CIC	EZH2	IGF2R	MARK4	NTRK3	RALGDS	TCL1A
24	AURKC	CKS1B	FAM123B	IKBKB	MBD1	NUMA1	RARA	TET1
25	AXL	CMPK1	FANCA	IKBKE	MCL1	NUP214	RB1	TET2
26	BAI3	COL1A1	FANCC	IKZF1	MDM2	NUP98	RECQL4	TFE3
27	BAP1	CRBN	FANCD2	IL2	MDM4	PAK3	REL	TGFBR2
28	BCL10	CREB1	FANCF	IL21R	MEN1	PALB2	RET	TGM7
29	BCL11A	CREBBP	FANCG	IL6ST	MET	PARP1	RHOH	THBS1
30	BCL11B	CRKL	FAS	IL7R	MITF	PAX3	RNASEL	TIMP3
31	BCL2	CRTC1	FBXW7	ING4	MLH1	PAX5	RNF2	TLR4
32	BCL2L1	CSF1R	FGFR1	IRF4	MLL	PAX7	RNF213	TLX1
33	BCL2L2	CSMD3	FGFR2	IRS2	MLL2	PAX8	ROS1	TNFAIP3
34	BCL3	CTNNA1	FGFR3	ITGA10	MLL3	PBRM1	RPS6KA2	TNFRSF14
35	BCL6	CTNNB1	FGFR4	ITGA9	MLLT10	PBX1	RRM1	TNK2
36	BCL9	CYLD	FH	ITGB2	MMP2	PDE4DIP	RUNX1	TOP1
37	BCR	CYP2C19	FLCN	ITGB3	MN1	PDGFB	RUNX1T1	TP53
38	BIRC2	CYP2D6	FLI1	JAK1	MPL	PDGFRA	SAMD9	TPR
39	BIRC3	DAXX	FLT1	JAK2	MRE11A	PDGFRB	SBDS	TRIM24
40	BIRC5	DCC	FLT3	JAK3	MSH2	PER1	SDHA	TRIM33
41	BLM	DDB2	FLT4	JUN	MSH6	PGAP3	SDHB	TRIP11
42	BLNK	DDIT3	FN1	KAT6A	MTOR	PHOX2B	SDHC	TRRAP
43	BMPR1A	DDR2	FOXL2	KAT6B	MTR	PIK3C2B	SDHD	TSC1
44	BRAF	DEK	FOXO1	KDM5C	MTRR	PIK3CA	SEPT9	TSC2
45	BRD3	DICER1	FOXO3	KDM6A	MUC1	PIK3CB	SETD2	TSHR
46	BRIP1	DNMT3A	FOXP1	KDR	MUTYH	PIK3CD	SF3B1	UBR5
47	BTK	DPYD	FOXP4	KEAP1	MYB	PIK3CG	SGK1	UGT1A1
48	BUB1B	DST	FZR1	KIT	MYC	PIK3R1	SH2D1A	USP9X
49	CARD11	EGFR	G6PD	KLF6	MYCL1	PIK3R2	SMAD2	VHL
50	CASC5	EML4	GATA1	KRAS	MYCN	PIM1	SMAD4	WAS