Figure 6. A new SARS-CoV-2 3CLpro groove binding site in conformations A (left, red) and B (right, blue) in complexes with hit molecules 19-hydroxypenitrem A (light blue), 2′,3′-epoxymyrothecine A (indigo) and pseudonocardone C (orange).

His 41 and Cys 141 residues are depicted in yellow, the C-terminus’ last helix region in cyan, the N-finger in tan and residues 288–290 in light blue.