Fig. 6.

Wound outcomes by Day 24 with treatments indicated for each pig. Wounds that were inoculated with planktonic bacteria are shown in the panels on the left. Wounds inoculated with biofilms are shown in the panels on the right. Positive control wounds (Pig 1) that were undebrided had not yet healed fully with eschar, incomplete contraction and reepithelialization still occurring. Debrided wounds in Pig 1 were largely healed by Day 24, yet still showed signs of incomplete contraction and reepithelialization (see arrows). Representative wounds treated with CZ-01179 gel or SSD cream are shown for Pig 2. By Day 24, wounds were healed in Pig 2 with scarring present. Wounds in Pig 3 had not fully reepithelialized by Day 24 and were still contracting, in particular those that were undebrided. Wounds that were treated with both IV and topical antimicrobials (Pig 4) looked similar in nature to those in Pig 2.