Table II. Acyl chain compositions of bulk brain lipids.
Fatty acid compositions of the lipid classes analyzed from pooled brain tissue samples depicted in Fig. 7 were determined by Lipomics TrueMass™ technology. Profiles of the indicated fatty acid species (at left) for the indicated lipid species (at top) are presented in nanomoles of fatty acid/total moles of fatty acid in each lipid class. The data are presented as PITPα+/+ value/PITPα−/− value. Some differences between corresponding PITPα+/+ and PITPα−/− values are indicated in boldfase. Omega fatty acid nomenclature is employed. The t prefix indicates trans-double bond, and the dm prefix indicates plasmalogen-linked fatty acid. SM indicates sphingomyelin. A precise molecular description of each fatty acid species analyzed is provided at www.lipomics.com/Fatty%20Acids/fatty_acid.htm.
| Acyl species | CE | TG | DAG | FFA | SM | CL |
|---|---|---|---|---|---|---|
| 14:0 | 5.4/6.0 | 3.3/0.0 | 4.1/5.4 | 4.1/4.2 | 2.6/3.5 | 1.9/2.0 |
| 14:1n5 | 0.0/0.0 | 0.7/1.0 | 0.0/0.0 | 0.0/0.0 | 0.1/0.2 | 0.0/0.0 |
| 15:0 | 1.0/1.6 | 1.6/2.8 | 0.8/1.1 | 1.3/1.0 | 0.5/1.1 | 1.2/1.7 |
| dm16:0 | 1.7/3.3 | 0.7/1.3 | 0.0/0.4 | 0.0/0.3 | 0.2/0.3 | 2.6/3.1 |
| 16:0 | 23.2/21.4 | 27.2/28.5 | 28.9/36.0 | 33.4/33.9 | 17.1/16.8 | 16.1/16.9 |
| t16:1n7 | 0.9/1.8 | 0.7/1.3 | 3.1/3.3 | 5.4/5.5 | 1.6/2.6 | 0.5/2.2 |
| 16:1n7 | 9.1/13.2 | 3.7/5.6 | 1.3/1.4 | 1.2/0.9 | 1.3/1.8 | 3.3/1.8 |
| dm18:0 | 0.0/0.0 | 0.9/0.7 | 0.0/0.0 | 0.4/0.7 | 0.2/0.1 | 1.8/2.1 |
| dm18:1n9 | 1.9/2.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.1/0.2 |
| dm18:1n7 | 0.0/0.0 | 0.8/1.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.2/0.2 |
| 18:0 | 16.4/11.9 | 15.4/18.8 | 23.4/27.9 | 27.4/30.4 | 28.7/23.2 | 21.8/18.9 |
| t18:1n9 | 0.0/0.0 | 0.0/0.0 | 0.0/0.4 | 0.0/0.0 | 0.3/0.9 | 0.0/0.0 |
| 18:1n9 | 12.3/11.5 | 17.3/18.2 | 15.2/8.7 | 12.2/10.7 | 18.4/25.0 | 6.0/6.0 |
| 18:1n7 | 0.6/0.0 | 1.5/1.2 | 1.6/1.0 | 1.5/1.3 | 1.7/1.7 | 2.1/1.5 |
| t18:2n6 | 0.0/0.0 | 0.0/0.0 | 0.2/0.3 | 0.0/0.1 | 0.0/0.0 | 0.0/0.0 |
| 18:2n6 | 7.2/6.8 | 16.3/8.9 | 9.1/4.8 | 6.1/4.2 | 2.7/3.1 | 8.4/2.8 |
| 18:3n6 | 0.0/0.6 | 0.3/0.6 | 0.3/0.0 | 0.2/0.0 | 0.0/0.0 | 0.0/0.0 |
| 18:3n3 | 0.2/0.0 | 0.6/0.4 | 0.8/0.8 | 0.3/0.4 | 0.4/0.4 | 0.4/0.3 |
| 18:4n3 | 0.0/0.3 | 0.3/0.5 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.2/0.2 |
| 20:0 | 0.4/1.0 | 0.8/0.4 | 0.8/0.7 | 0.9/0.9 | 0.4/0.3 | 0.2/0.2 |
| 20:1n15 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 |
| 20:1n12 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 |
| 20:1n9 | 6.2/5.6 | 1.1/2.0 | 0.4/0.0 | 0.2/0.3 | 0.5/0.4 | 0.4/0.2 |
| 20:3n9 | 0.0/0.0 | 0.0/0.0 | 0.3/1.4 | 0.5/0.4 | 0.1/0.1 | 0.0/0.1 |
| 20:2n6 | 0.7/0.9 | 0.8/0.3 | 0.3/0.5 | 0.4/0.4 | 0.1/0.2 | 16.9/25.2 |
| 20:3n6 | 0.0/0.0 | 1.0/0.3 | 0.4/0.0 | 0.4/0.3 | 0.6/0.5 | 0.5/0.4 |
| 20:4n6 | 1.1/0.0 | 1.4/0.4 | 7.7/2.8 | 3.5/1.9 | 4.5/3.3 | 4.4/4.1 |
| 20:3n3 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.1 | 0.1/0.0 |
| 20:4n3 | 0.0/0.0 | 0.3/0.2 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.3/0.3 |
| 20:5n3 | 0.0/0.0 | 0.3/0.0 | 0.2/0.0 | 0.0/0.1 | 0.0/0.0 | 0.0/0.1 |
| 22:0 | 1.1/1.8 | 0.3/0.3 | 0.0/0.0 | 0.0/1.1 | 0.6/0.4 | 0.1/0.2 |
| 22:1n9 | 9.3/8.6 | 1.3/0.3 | 0.0/1.1 | 0.0/0.4 | 0.4/0.3 | 0.3/0.4 |
| 22:2n6 | 0.0/0.3 | 0.0/0.0 | 0.0/2.1 | 0.0/0.2 | 0.0/0.1 | 0.7/0.6 |
| 22:4n6 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.2/0.2 | 0.4/0.0 |
| 22:5n6 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 |
| 22:5n3 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.6/0.4 | 0.1/0.2 |
| 22:6n3 | 0.0/0.0 | 0.3/0.3 | 1.1/0.0 | 0.0/0.0 | 15.9/12.4 | 8.5/7.3 |
| 24:0 | 1.3/1.5 | 0.8/0.3 | 0.0/0.0 | 0.5/0.6 | 0.2/0.3 | 0.2/0.4 |
| 24:1n9 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.2/0.4 | 0.2/0.3 |
| 24:6n3 | 0.0/0.0 | 0.2/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 | 0.0/0.0 |