Table 2.
Patient counts, event counts and incidence rates (IRs; per 1000 person-years) of key events according to drug use.
| 30-day follow-up |
On-treatment follow up |
||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Patients |
Events |
IR (/1000 py) |
Patients |
Events |
IR (/1000 py) |
||||||||
| Outcome | Database | T | C | T | C | T | C | T | C | T | C | T | C |
| Depression | AmbEMR | 55 793 | 15 092 | 155 | 29 | 33.91 | 23.44 | 55 793 | 15 092 | 320 | 80 | 17.74 | 14.34 |
| CCAE | 66 440 | 22 449 | 79 | 28 | 14.64 | 15.36 | 66 440 | 22 449 | 557 | 137 | 8.54 | 9.40 | |
| Clinformatics | 51 676 | 16 812 | 84 | 41 | 20.05 | 30.09 | 51 676 | 16 812 | 657 | 178 | 12.43 | 15.00 | |
| CPRD | 9160 | 11 348 | <5 | 8 | <6.67 | 8.60 | 9160 | 11 348 | 36 | 94 | 1.99 | 3.60 | |
| DAGermany | 3937 | 5109 | <5 | 12 | <15.48 | 28.63 | 3937 | 5109 | 40 | 70 | 15.47 | 19.66 | |
| IMRD | 8844 | 8456 | <5 | 6 | <6.91 | 8.67 | 8844 | 8456 | 38 | 51 | 2.20 | 2.72 | |
| MDCD | 7950 | 2286 | 14 | 6 | 21.61 | 32.29 | 7950 | 2286 | 90 | 13 | 15.81 | 10.12 | |
| MDCR | 15 735 | 5275 | 13 | 6 | 10.14 | 13.98 | 15 735 | 5275 | 97 | 38 | 5.37 | 9.27 | |
| OpenClaims | 620 081 | 183 312 | 654 | 161 | 12.85 | 10.70 | 620 081 | 183 312 | 4810 | 957 | 5.59 | 5.58 | |
| OptumEHR | 78 528 | 20 244 | 321 | 66 | 50.56 | 40.30 | NA | NA | NA | NA | NA | NA | |
| Meta-analysis | 918 144 | 290 383 | <1335 | 363 | <17.77 | 15.28 | 839 616 | 270 139 | 6645 | 1618 | 6.28 | 6.29 | |
| Suicide and suicidal ideation | AmbEMR | NA | NA | NA | NA | NA | NA | 57 660 | 15 357 | 6 | <5 | 0.32 | <0.88 |
| CCAE | 66 533 | 22 471 | 12 | <5 | 2.22 | <2.74 | 66 533 | 22 471 | 81 | 28 | 1.23 | 1.91 | |
| Clinformatics | 51 807 | 16 843 | 12 | <5 | 2.85 | <3.66 | 51 807 | 16 843 | 97 | 30 | 1.80 | 2.50 | |
| CPRD | 9167 | 11 358 | <5 | <5 | <6.66 | <5.37 | 9167 | 11 358 | 7 | 9 | 0.39 | 0.34 | |
| IMRD | 8852 | 8460 | <5 | <5 | <6.91 | <7.22 | 8852 | 8460 | 8 | 6 | 0.46 | 0.32 | |
| MDCD | 7980 | 2296 | <5 | <5 | <7.68 | <26.78 | 7980 | 2296 | 56 | 18 | 9.71 | 14.08 | |
| MDCR | NA | NA | NA | NA | NA | NA | 15 752 | 5278 | 15 | 6 | 0.83 | 1.45 | |
| OpenClaims | 621 067 | 183 550 | 34 | 8 | 0.67 | 0.53 | 621 067 | 183 550 | 321 | 89 | 0.37 | 0.52 | |
| OptumEHR | 79 903 | 20 480 | 18 | 8 | 2.78 | 4.82 | NA | NA | NA | NA | NA | NA | |
| Meta-analysis | 845 309 | 265 458 | <91 | <41 | <1.31 | <1.89 | 838 818 | 265 613 | 591 | <191 | 0.55 | <0.75 | |
| Hospitalization for psychosis | OpenClaims | 620 964 | 183 527 | 95 | 27 | 1.86 | 1.79 | 620 964 | 183 527 | 1108 | 221 | 1.28 | 1.28 |
| OptumEHR | 79 994 | 20 508 | <5 | <5 | <0.77 | <3.01 | NA | NA | NA | NA | NA | NA | |
| Meta-analysis | 700 958 | 204 035 | <100 | <32 | <1.74 | <1.91 | NA | NA | NA | NA | NA | NA | |
T, target therapy; C, comparator therapy; IR, incidence rate; py, person-years at risk; NA, not applicable (not reported because of failed diagnostics or on-treatment follow-up unavailable); AmbEMR, IQVIA Ambulatory EMR; CCAE, IBM Commercial Database; Clinformatics, Optum de-identified Clinformatics Data Mart Database; CPRD, Clinical Practice Research Datalink; DAGermany, IQVIA Disease Analyzer Germany; IMRD, IQVIA UK Integrated Medical Record Data; MDCD, IBM Multistate Medicaid; MDCR, IBM Medicare Supplemental Database; OpenClaims, IQVIA Open Claims; OptumEHR, Optum de-identified Electronic Health Record dataset.