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. 2020 Dec 3;223(5):785–795. doi: 10.1093/infdis/jiaa753

Figure 2.

Figure 2.

Coronavirus disease 2019 convalescent plasma (CP) blocks the entry of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in human monocyte-derived macrophages (MDMs). SARS-CoV-2 was incubated with CP or control plasma as described in the Materials and Methods before infecting human MDMs. A and B, N protein expression in SARS-CoV-2–infected MDMs treated with CP or control plasma was determined by flow cytometry at indicated time points. C, SARS-CoV-2 N RNA expression in MDMs was detected by quantitative polymerase chain reaction. B and C, Data are shown as mean ± standard error of the mean and are representative of 3 independent experiments (n = 4–6). *P < .05; **P < .01; ***P < .001. Abbreviations: APC, antigen-presenting cell; CP, convalescent plasma; Ctrl, control; HPRT, hypoxanthine-guanine phosphoribosyltransferse; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2.