Table 5.

MR results from sensitivity analysis with linkage-disequilibrium coefficient (r²) <10% and without SNPs at risk of pleiotropy

Inverse-variance weighted MR meta-analysis		MR-Egger meta-analysis
Odds ratio (95% CI)	p-value	Intercept	Alpha p-value	Odds ratio (95% CI)	Odds ratio p-value
Susceptibility
1.02 (0.95, 1.11)	0.54	–0.02 (–0.08, 0.04)	0.59	0.98 (0.84, 1.16)	0.85
Extended susceptibility
1.02 (0.95, 1.09)	0.62	0.01 (–0.05, 0.06)	0.77	1.04 (0.89, 1.21)	0.64
Hospitalized
0.878 (0.73, 1.06)	0.19	0.02 (–0.12, 0.16)	0.75	0.93 (0.63, 1.37)	0.73
Extended hospitalized
0.982 (0.87, 1.11)	0.78	–0.005 (–0.10, 0.09)	0.93	0.97 (0.74, 1.27)	0.84
Severe disease
0.784 (0.58, 1.06)	0.12	0.06 (–0.16, 0.28)	0.58	0.92 (0.50, 1.70)	0.80
Extended severe disease
0.986 (0.82, 1.18)	0.88	–0.007 (–0.15, 0.14)	0.93	0.97 (0.65, 1.44)	0.88

Odds ratios are presented for a decrease in 1 standard deviation in angiotensin-converting enzyme level. CI, confidence interval.