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. 2020 Dec 18:bbaa376. doi: 10.1093/bib/bbaa376

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© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Targeted immune profiling of SARS-CoV-2 infected patient blood samples reveals systemic immune responses to infection, and perturbed cell signalling pathways that overlap with primary lung infection effects. (A) Heat map of targeted immune RNA profile of 32 patients (n = 10 healthy controls, n = 23 SARS-CoV-2 infected patients) using a NanoString-targeted immunology panel shows SARS-CoV-2 infected patients have a distinct systemic infection response. (B) A pooled analysis of time-course data reveals top gene dysregulated in patient blood by SARS-CoV-2 infection. (C) Only three genes are seen to be overlapping between primary lung cell and blood cell infection responses. (D) Nevertheless, we see concordance at the level of perturbed cell signalling pathways related to immune-inflammatory cytokine and interferon responses in the host.