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. 2020 Dec 8:bbaa329. doi: 10.1093/bib/bbaa329

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© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Binding mode between human ACE2 and 2019-nCoV-Spike. (A) Conformation of 2019-nCoV/ACE2 complex. (B/C) Detailed binding modes between ACE2 and 2019-nCoV Spike region. (D) 18 residues of ACE2 forming direct interactions with 2019-nCoV. The 14 key polar residues of human ACE2 were shown as red spheres. The ACE2 protein: green, labeled as black; 2019-nCoV: orange; 2019-nCoV-Spike region: white.