Table 1.
Sequence alignment of 14 key polar residues in 22 different species
| Species | Scientific name | Key polar residues of ACE2 in different species | Sequence similarity | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 24 | 27 | 28 | 30 | 31 | 34 | 35 | 37 | 38 | 41 | 42 | 79 | 82 | 83 | 330 | 353 | 355 | 357 | Full- | Key polar- | ||
| Rat | Mus musculus | Q | E | F | K | Q | A | R | D | D | Y | A | L | M | Y | N | K | D | R | 84.25% | 57.14% |
| Chicken | Gallus gallus | Q | T | F | A | E | V | R | E | D | Y | E | N | R | F | N | K | D | R | 70.25% | 57.14% |
| Snake | Thamnophis elegans | Q | E | F | K | Q | A | R | D | D | Y | A | L | M | Y | N | K | D | R | 64.13% | 57.14% |
| Duck | Anas platyrhynchos | Q | M | F | A | K | V | R | E | D | Y | E | N | N | F | N | K | D | R | 70.59% | 64.28% |
| Totoro | Chinchilla lanigera | Q | T | F | D | N | E | K | E | D | Y | Q | L | M | Y | N | K | D | R | 87.58% | 78.57% |
| Cat | Felis catus | L | T | F | E | K | H | E | E | E | Y | Q | L | T | Y | N | K | D | R | 86.10% | 78.57% |
| Manis | Manis javanica | E | T | F | E | K | S | E | E | D | Y | Q | I | N | Y | N | K | D | R | 85.40% | 78.57% |
| Rabbit | Oryctolagus cuniculus | L | T | F | E | K | Q | E | E | D | Y | Q | L | T | Y | N | K | D | R | 87.10% | 78.57% |
| Lion | Puma concolor | L | T | F | E | K | H | E | E | E | Y | Q | L | T | Y | N | K | D | R | 86.43% | 78.57% |
| Tiger | Panthera tigris altaica | L | T | F | E | K | H | E | E | E | Y | Q | L | M | Y | N | K | D | R | 86.43% | 78.57% |
| Sheep | Ovis aries | Q | T | F | E | K | H | E | E | D | Y | Q | M | T | Y | N | K | D | R | 82.89% | 92.85% |
| Whale | Physeter catodon | Q | T | F | Q | K | H | E | E | D | Y | Q | T | T | Y | N | K | D | R | 82.89% | 92.85% |
| Deer | Odocoileus virginianus | Q | T | F | E | K | S | E | E | D | Y | Q | M | T | Y | N | K | D | R | 82.38% | 94.44% |
| Chimpanzee | Pan paniscus | Q | T | F | D | K | H | E | E | D | Y | Q | L | M | Y | N | K | D | R | 99.50% | 100% |
| Human | Homo sapiens | Q | T | F | D | K | H | E | E | D | Y | Q | L | M | Y | N | K | D | R | 100% | 100% |
| Cow | Bos taurus | Q | T | F | E | K | H | E | E | D | Y | Q | L | M | Y | N | K | D | R | 82.72% | 92.85% |
| Dolphin | Phocoena sinus | Q | T | F | Q | K | H | E | E | D | Y | Q | I | M | Y | N | K | D | R | 81.21% | 92.85% |
| Monkey | Macaca mulatta | Q | T | F | D | K | H | E | E | D | Y | Q | L | M | Y | N | K | D | R | 96.82% | 100% |
| Cynomys | Marmota | L | T | F | D | K | Q | E | E | D | Y | Q | L | M | Y | N | K | D | R | 85.93% | 85.71% |
| Pig | Sus scrofa domesticus | L | T | F | E | K | L | E | E | D | Y | Q | I | T | Y | N | K | D | R | 82.75% | 78.57% |
| Dog | Canis lupus familiaris | L | T | F | E | K | Y | E | E | E | Y | Q | L | T | Y | N | K | D | R | 84.68% | 71.42% |
| Bat | Phyllostomus discolor | D | K | F | E | N | N | E | E | E | Y | Q | L | N | Y | N | K | D | R | 82.03% | 64.28% |
Nonpolar residues: 27, 28, 79 and 82; 14 polar residues: 24, 30, 31, 34, 35, 37, 38, 41, 42, 83, 330, 353, 355 and 357.