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. 2020 Dec 22;22(2):742–768. doi: 10.1093/bib/bbaa362

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© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com

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PMC Copyright notice

Antiviral drugs repurposed against COVID-19, for which 3D structures of the ligand-protein complex were determined experimentally. Both approved drugs against chronic hepatitis C, boceprevir and telaprevir, inhibit SARS-CoV-2 main protease (3CLpro) and are clinically evaluated in different association. Veterinary molecule against feline CoV infection, GC376, is a prodrug generating an irreversible nanomolar 3CLpro inhibitor and will probably enter clinical phase. Remdesivir, a late development drug against Ebola virus, is a SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp) strong inhibitor and received emergency use authorization for COVID-19 in Europe and USA. Favipiravir, used in influenza infection, is a RdRp inhibitor investigated against SARS-CoV-2 infection.