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. 2020 Dec 31:pvaa138. doi: 10.1093/ehjcvp/pvaa138

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

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Severe/critical CoViD-19 in patients with history of hypertension. (A) Random effects meta-analysis. ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin-receptor blocker; CoViD-19, coronavirus disease 2019. All studies were published in the year 2020. Definitions of severe and critical are detailed in Supplementary material online, Table S1 footnote. Liu Y (ACEi/ARB numbers manually calculated with assumption that no patients used ACEi and ARB at the same time). (B) Funnel plot. Egger’s test for small-study effects (14 studies): estimated bias coefficient −1.861, standard error 0.811, P-value = 0.041.