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. 2020 Dec 31:pvaa138. doi: 10.1093/ehjcvp/pvaa138

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2021. For permissions, please email: journals.permissions@oup.com.

This article is made available via the PMC Open Access Subset for unrestricted re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the COVID-19 pandemic or until permissions are revoked in writing. Upon expiration of these permissions, PMC is granted a perpetual license to make this article available via PMC and Europe PMC, consistent with existing copyright protections.

This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model)

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Composite of mechanical ventilation/ITU/death in patients with history of hypertension who had CoViD-19. (A) Random effects meta-analysis. ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin-receptor blocker; CoViD-19, coronavirus disease 2019; ITU, intensive therapy unit; USA, United States of America. All studies were published in the year 2020. Kim JH (ITU/ventilator/death/sepsis). Mancia (ACEi/ARB numbers manually calculated with assumption that no patients used ACEi and ARB at the same time) (critical/fatal = ventilator/death). Mehta (includes previously unpublished data from authors). Reynolds (severe outcome = ITU/ventilator/death). (B) Funnel plot. Egger’s test for small-study effects (13 studies): estimated bias coefficient −1.141, standard error 0.670, P-value = 0.117.