Table 2.
The selected six most potential CD4+ T-cell epitopes along with their interacting MHC class-II alleles with affinity IC50 < 100
| S. No. | Epitopes | Position | Interacting MHC class-II allele | IC50 values (<100) |
|---|---|---|---|---|
| 1 | FVSNGTHWF | 1095–1103 | HLA-DRB1*01:01 | 21.43 |
| HLA-DRB1*13:02 | 93.35 | |||
| HLA-DRB1*07:01 | 89.95 | |||
| HLA-DRB1*13:02 | 47.25 | |||
| HLA-DRB1*09:01 | 98.31 | |||
| 2 | IRASANLAA | 1018–1026 | HLA-DRB1*01:01 | 19.9 |
| HLA-DRB1*04:01 | 97.67 | |||
| HLA-DRB1*13:02 | 42.12 | |||
| HLA-DRB1*07:01 | 84 | |||
| HLA-DRB1*09:01 | 88.15 | |||
| 3 | FGAISSVLN | 970–978 | HLA-DRB1*01:01 | 20.2 |
| HLA-DRB1*04:01 | 98.03 | |||
| HLA-DRB1*04:05 | 96.39 | |||
| HLA-DRB1*07:01 | 86.61 | |||
| HLA-DRB1*09:01 | 88.46 | |||
| 4 | VKQLSSNFG | 963–971 | HLA-DRB1*01:01 | 22.84 |
| HLA-DRB1*15:01 | 91.6 | |||
| HLA-DRB1*04:01 | 85.68 | |||
| 5 | FAMQMAYRF | 898–906 | HLA-DRB1*01:01 | 12.49 |
| HLA-DRB1*07:01 | 42.09 | |||
| HLA-DRB1*09:01 | 53.55 | |||
| HLA-DRB1*11:01 | 48.76 | |||
| HLA-DRB1*15:01 | 50.31 | |||
| 6 | FGAGAALQI | 888–896 | HLA-DRB1*01:01 | 16.21 |
| HLA-DRB1*09:01 | 24.83 | |||
| HLA-DRB1*07:01 | 48.18 |