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. 2020 Dec 21;22(2):1338–1345. doi: 10.1093/bib/bbaa385

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© The Author(s) 2020. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Circos plot of IRs and CpGs overlay with SARS-CoV-2 hot-spot mutations. Outer circle—nucleotide positions, second circle—gene annotations (ORFs are designated by their common symbols [S for spike glycoprotein, E for envelope protein, M for membrane glycoprotein, and N for nucleocapsid phosphoprotein]). Orange—IR presence, blue—CpG island presence (heights of CpG peaks correspond proportionally to their score by newcpgpeak [higher peak = higher score]). Red—hot-spot mutations (heights of hot-spot mutations bands proportionally express their frequencies in all analyzed genomes). The grey circle separates the descriptive (outer) and analytics (inner) part of the plot.