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. 2020 Dec 2:znaa021. doi: 10.1093/bjs/znaa021

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© The Author(s) 2020. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please email: journals.permissions@oup.com.

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Fig. 1 — Blood concentrations of inflammatory mediators in patients with severe COVID-19 in the two treatment groups and the subgroups with diarrhoea

a Interleukin (IL) 6; b IL-6 in subgroups with diarrhoea; c tumour necrosis factor (TNF) α; d TNF-α in subgroups with diarrhoea; e C-reactive protein (CRP); f CRP in subgroups with diarrhoea; g procalcitonin; h procalcitonin in subgroups with diarrhoea; i white blood cell count (WBC); j WBC in subgroups with diarrhoea. Values are median (i.q.r.). There were 18 patients in the berberine group and 17 in the control group, with six and five patients in the respective subgroups with diarrhoea. *P < 0.050, berberine versus control group (generalized linear mixed model).