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. 2020 Nov 30;13(1):e12828. doi: 10.15252/emmm.202012828

Figure 8. Proposed model for the role of the decoy antibody ACE2‐Fc in SARS‐CoV‐2 entry and infection.

Figure 8

The decoy antibody (ACE2‐Fc) not only reduces SARS‐CoV‐2 infection but also decreases TNF‐α secretion and ADAM‐17 phosphorylation mediated by angiotensin II. Ang II: angiotensin II; ARDS: acute respiratory distress syndrome; CatB/L: cathepsin B and L; PPRs: pattern recognition receptors; AMP: amplifier; STAT3: Signal transducer and activator of transcription 3; ATIR: angiotensin II type I receptor; ADAM17: a disintegrin and metalloprotease 17; TMPRSS2: transmembrane Serine Protease 2.