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. 2020 Dec 7;13(1):e13207. doi: 10.15252/emmm.202013207

Figure EV4. The drug combination ND‐011992‐Q203 is bactericidal against Mycobacterium bovis BCG.

Figure EV4

  1. Bactericidal activity of ND‐011992 and ND‐011992‐Q203 combination in replicating M. bovis BCG. Q203 was used at 100 nM, and ND‐011992 used at 3, 6, 12, and 30 μM alone or in combination with Q203. Dotted line represents 90% reduction in CFU/ml compared with the initial inoculum at time 0. Exact P‐values (from left to right): 0.0002, 0.0002, 0.0003, 0.00002.
  2. Bactericidal activity of ND‐011992 and ND‐011992‐Q203 combination in M. bovis BCG under oxygen‐starved condition. Metronidazole (MTZ) was used at 200 μM, Q203 was used at 100 nM, and ND‐011992 was used at 3, 6, 12, and 30 μM. Bacterial viability was determined via CFU enumeration after 10 days of treatment. Dotted line represents 99% reduction in CFU/mL compared with the initial inoculum at time 0. Exact P‐values (from left to right): 0.0024, 0.0075, 0.0029, 0.0000003.

Data information: **P < 0.01, unpaired Student’s t‐test, one‐tailed; n = 3; comparing Q203 alone vs Q203 + ND‐011992. Data are expressed as the mean ± SD of triplicates for each condition.