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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Aug 22;518:110999. doi: 10.1016/j.mce.2020.110999

Figure 1. GHR signaling pathways.

Figure 1.

This figure summarizes the GHR signaling pathways discussed in the text. Major signaling systems engaged downstream of the GH-engaged GHR-JAK2 complex are shown. These include the STATs, ERKs, and PI3K pathways. Intermediate molecules on these pathways are shown, as are loci of crosstalk with EGFR. Yp indicates tyrosine phosphorylation. Other pathways referred to in the text are indicated in boxes, as are cell biological and biochemical outcomes of activated pathways.