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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Aug 22;518:110999. doi: 10.1016/j.mce.2020.110999

Figure 2. Role of IGF-1R-GHR interaction in augmenting GH signaling in the context of the somatomedin hypothesis.

Figure 2.

A) Somatomedin hypothesis. GH binds GHR, activating JAK2/STAT5 and IGF-1 production. IGF-1 then acts in an endocrine fashion, stimulating IGF-1R signaling. B,C) GH promotes GHR-IGF-1R association. IGF-1R acts as a component of GH signaling (B). In IGF-1R’s absence (or reduction) (red X)(C), GH action is reduced. See the text for discussion.