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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Aug 22;518:110999. doi: 10.1016/j.mce.2020.110999

Figure 3. Putative IGF-1R-associated accessory protein(s) augment GH signaling.

Figure 3.

A) GH enhances association of GHR/JAK2 with IGF-1R and an IGF-1R-associated protein(s), “X”, augmenting GH signaling. “X” is cartooned as a transmembrane protein to suggest likely association with IGF-1R ECD and actions exerted intracellularly, but “X” could be a protein complex that either augments signaling or lessens down-regulation of signaling. B) In IGF-1R’s absence, GH does not induce “X” to join the GHR/JAK2 signaling complex and signaling is relatively diminished. CR-L2 region of IGF-1R ECD is shown in solid black and is envisioned as the region of IGF-1R that interacts with GHR. See the text for discussion.