Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Aug 22;518:110999. doi: 10.1016/j.mce.2020.110999

Figure 4. Putative effects of sol IGF-1R on GH signaling.

Figure 4.

A) GH enhances association of GHR/JAK2 with IGF-1R, augmenting GH signaling, as in Figure 3A. Strong GH-induced signaling is indicated by “SIGNAL”. B) GH induces GHR/sol IGF-1R association and dampened signaling ensues. Sol IGF-1R contains the L1-CR-L2 region (CR-L2 region in black). Sol IGF-1R allows GH-induced GHR and JAK2 conformational changes and signaling, but competes with IGF-1 R for GHR association. GH signaling is similar in strength as with IGF-1R silencing seen in Figure 3B. See the text for discussion.