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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: Mol Cell Endocrinol. 2020 Aug 22;518:110999. doi: 10.1016/j.mce.2020.110999

Figure 5. Potential selective modulation of local GH action in IGF-1R-expression GH target tissues.

Figure 5.

A) In IGF-1R-negative tissues (such as liver), GH induces STAT5 signaling and other GH actions, culminating with IGF-1 secretion and endocrine actions, but not local IGF-1 effects. B) In IGF-1R-positive tissues (designated as extrahepatic) the presence of IGF-1R augments GH signaling (as above) and local IGF-1 production, which exerts further local effects via the IGF-1R, thereby augmenting the dynamic range of GH/IGF-1 action without necessarily changing the circulating GH or IGF-1 levels. See the text for discussion.