Table 3.

Absorption, distribution, metabolism and excretion (ADME) and other pharmacokinetic properties of selected phytochemicals from Phyllanthus amarus and Andrographis paniculata

S. L. No.	Group	Compound	HIA	Carcinogens	logS value	MW	HBD	HBA	logP value	Rule of 5 violations
1	Positive control	Remdesivir	0.9135 (low)	NC	− 3.474	602.58	4	12	3.4	2
2	Flavonoids	Astragalin	0.6347 (low)	NC	− 2.449	448.38	7	11	1.29	2
3		Kaempferol	0.9881 (high)	NC	− 3.142	286.24	4	6	1.7	0
4		Quercetin	0.9883 (high)	NC	− 2.999	302.24	5	7	1.63	0
5		quercetin-3-O-glucoside	0.6468 (low)	NC	− 2.449	464.38	8	12	0.94	2
6		Quercitrin	0.7322 (low)	NC	− 3.497	448.38	7	11	1.6	2
7	Phenylpropanoid	Hinokinin	0.9784 (high)	NC	− 3.113	354.35	0	6	3.08	0
8	Tannins	corilagin	0.8598 (low)	NC	− 2.727	634.45	11	18	1.48	3
9		Furosin	0.8598 (low)	NC	− 2.75	634.45	11	18	1.48	3
10		geraniin	0.8592 (low)	NC	− 3.172	954.66	14	27	0.67	3
11	Bioactive compound	Isoandrographolide	0.9822 (high)	NC	− 2.853	350.45	3	5	2.45	0
12	Diterpenes	14-deoxy-14,15-didehydroandrographolide	0.9773 (high)	NC	− 2.927	332.43	2	4	2.96	0
13		14-Deoxyandrographolide	0.9899 (high)	NC	− 2.816	334.45	2	4	2.79	0
14		19-O-Acetyl-14-deoxy-11,12-didehydroandrographolide	0.9764 (high)	NC	− 4.139	374.47	1	5	3.48	0
15		Neoandrographolide	0.8124 (low)	NC	− 3.313	480.59	4	8	3.37	0
16	Flavonoids	5-hydroxy-7,8,2′,5′-tetramethoxy flavone	0.4104 (low)	NC	− 2.678	520.48	4	12	3.22	2

HIA human intestinal absorption (probability), logS solubility, MW molecular weight (Dalton), HBD hydrogen bond donor, HBA hydrogen bond acceptor, logP liphophilicity, Rule of 5 violations Lipinski rule of 5 and NC-Non carcinogen