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. Author manuscript; available in PMC: 2021 Jul 6.
Published in final edited form as: Nat Methods. 2021 Jan 6;18(1):92–99. doi: 10.1038/s41592-020-01020-3

Extended Data Fig. 1.

Extended Data Fig. 1

Details of the stacked auto-encoder for TCR embedding. (a) The structure of the auto-encoder, with the configurations of each layer shown. (b) Typical examples of TCR CDR3b sequences, heatmaps of the initially embedded ‘Atchley’ matrices of TCRs, and heatmaps of the auto-encoder-reconstructed ‘Athley’ matrices. The TCR sequence examples were not used in the training step of the auto-encoder. (c) Scatterplots showing the consistency between the ‘Atchley factor’ values of the original and re-constructed TCRs. Green points represent tiles in the heatmaps in (b).