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. 2021 Jan 11;16(1):e0245152. doi: 10.1371/journal.pone.0245152

Table 4. Twin pregnancy associated with neonatal and maternal outcomes by order of birth.

  All twins (n = 554) Singletons (n = 23,746) All twins (vs. Single) Twin A (n = 277) Twin B (n = 277) Twin B (vs. Twin A)
n (%) n (%) adj. OR* (95%CI) n (%) n (%) OR**(95%CI)
Birth weight
    Mean (SD) 2240g (573g) 3156g (573g) NA 2249g (558g) 2193g (546g) NA
    Low birth weight (< 2500 g) 353 (63.7) 2116 (8.9) 6.7 (4.6–9.9) 176 (63.5) 195 (70.4) 1.0 (0.9–1.1)
    SGA 202 (36.5) 1822 (7.7) 7.3 (4.7–11.2) 103 (37.2) 99 (35.7) 0.9 (0.8–1.1)
    IUGR 103 (18.6) 746 (3.1) 3.3 (1.9–5.8) 51 (18.4) 52 (18.8) 1.0 (0.9–1.1)
Neonatal and maternal outcomes
    Resuscitation 83 (15.0) 1769 (7.4) 0.7 (0.4–1.4) 35 (12.6) 48 (17.3) 1.5 (0.9–2.3)
    Oxygen therapy 161 (29.1) 1538 (6.5) 2.4 (1.0–5.5) 72 (26.0) 89 (32.1) 1.3 (1.1–1.6)
    Antibiotic use 124 (22.4) 1184 (5.0) 1.6 (1.0–2.6) 50 (18.1) 74 (26.7) 1.7 (1.3–2.1)
    Neonatal ICU admission 172 (31.0) 1497 (6.3) 3.8 (1.6–8.7) 78 (28.2) 94 (33.9) 1.3 (0.9–2.1)
    Transient tachypnea 82 (14.8) 773 (3.3) 1.8 (1.1–2.9) 36 (13.0) 46 (16.6) 1.3 (0.9–1.9)
    Hypoglycemia 33 (6.2) 284 (1.2) 1.4 (0.6–3.2) 13 (4.7) 20 (7.2) 1.6 (0.7–3.6)
    Phototherapy (jaundice) 151 (27.3) 1080 (4.5) 3.4 (2.4–4.7) 58 (20.9) 93 (33.6) 2.0 (1.5–2.6)
    Stillbirth 6 (1.1) 263 (1.1) 1.0 (0.99–1.01) 3 (1.1) 3 (1.1) 1.0 (0.98–1.02)
    Neonatal death 27 (4.9) 241 (1.0) 4.6 (2.4–8.3) 15 (5.4) 12 (4.3) 0.8 (0.48–1.16)
    Severe Neonatal Outcome Index a 247 (44.6) 2852 (12.0) 2.1 (1.4–3.3) 117 (51.5) 130 (57.3) 1.2 (0.9–1.5)
    Severe Maternal Outcome Indexb 8 (1.4) 264 (1.1) 0.3 (0.1–1.2) NA NA NA

* Adjusted for region, type of payment for birth (public or private), mother's age, years of schooling and gestational age at birth in weeks' gestation.

** There was no need for adjustment, since twins are from the same mother.

a Neonatal nearmisses, stillbitths or neonatal deaths.

b Maternal nearmisses (268 women) or maternal deaths (4 women).

NA: Logistic Regression not applicable.