Figure 8. The Linker of Nucleoskeleton and Cytoskeleton (LINC) complex as a branched network of SUN-KASH assemblies.

Model of the LINC complex as a branched network in which SUN-KASH 6:6 complexes act as nodes for force integration and distribution between two SUN trimers and three KASH dimers, which can bind to spatially separated and distinct nuclear and cytoskeletal components, respectively. This model enables cooperation between adjacent molecules within a LINC complex network to facilitate the transduction of large and coordinated forces across the nuclear envelope.