Fig. 2.

Alignment of the amino acid sequences of the DPF motifs of the MOZ, MORF, DPF1, DPF2, DPF3b, and PHF10-P human proteins. Schematic representation of the secondary structures of PHD1 and PHD2 is shown above the sequences. Cysteine and histidine residues coordinating Zn ions in PHD1 and PHD2 are indicated in blue and green, respectively. Homologous amino acids in PHD1 that form a hydrophobic pocket and bind H3K14ac/cr are highlighted in blue. Homologous amino acids that form an acidic pocket and bind to the first to fourth N-terminal amino acids of histone H3 are highlighted in green