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. 2021 Jan 7;14:97–110. doi: 10.2147/OTT.S266186

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© 2021 Wu et al.

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PTEN expression was regulated by miR-570-3p and circ_0007444. (A) The fragments of PTEN-WT and PTEN-Mut were designed and synthesized. (B) Luciferase reporter gene assay indicated that PTEN was a target gene of miR-570-3p. (C) qRT-PCR exhibited that miR-570-3p inhibited PTEN expression and circ_0007444 promoted PTEN expression in OC cells. (D) In OC patients, PTEN expression was prominently decreased in tumor tissues than that in adjacent normal tissues. (E) Pearson’s correlation analysis revealed a positive correlation between PTEN and circ_0007444 expression in tumor tissues of OC patients. (F) A negative correlation between PTEN and miR-570-3p expression was found in tumor tissues of OC patients according to Pearson’s correlation analysis. **P<0.01.