Table 3.
Median effective concentration (EC50) of caffeine in wild-type or mutant ryanodine receptor 1- (RYR1-) transfected cells. EC50 values were lower in mutant RYR1-transfected cells than in wild-type RYR1-transfected cells.
| RYR1 | n | Mean EC50 ± SD (mM) | 95% CI (mM) | P value | Cohen's d |
|---|---|---|---|---|---|
| Wild-type | 30 | 2.75 ± 0.81 | 2.46 to 3.10 | ||
| p.Thr84Met | 16 | 1.71 ± 0.43 | 1.49 to 1.95 | 0.000238 | 1.60 |
| p.Ser2345Arg | 22 | 1.82 ± 0.56 | 1.58 to 2.08 | 0.000405 | 1.33 |
| p.Ala4894Thr | 28 | 1.39 ± 0.55 | 1.18 to 1.60 | 0.000031 | 1.97 |
SD: standard deviation; n: number of cells examined; 95% CI: 95% confidence interval; P values, vs. wild-type.