Table 3. Summary of selected angiogenesis-related genes that decreased in the high-glucose (HG) group compared with the normal-glucose (NG) group.
Gene symbol | Fold change | Raw data (RC) | KEGG input | Transcript_id | Description | |||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
HG/NG | NG1 | NG2 | NG3 | NG4 | HG1 | HG2 | HG3 | HG4 | Entrez ID | |||
Wnt7b | 0.383 | 25 | 8 | 25 | 25 | 6 | 4 | 4 | 18 | 22422 | NM_009528 | Wingless-type MMTV integration site family, member 7B |
Ctgf | 0.432 | 26,261 | 28,683 | 26,265 | 26,262 | 12,606 | 12,690 | 12,153 | 15,186 | 14219 | NM_010217 | Connective tissue growth factor |
Ramp1 | 0.523 | 191 | 108 | 191 | 191 | 124 | 72 | 93 | 88 | 51801 | NM_016894 | Receptor (calcitonin) activity modifying protein 1 |
Nox1 | 0.542 | 47 | 18 | 47 | 47 | 23 | 15 | 23 | 29 | 237038 | NM_172203 | NADPH oxidase 1 |
Cxcl12 | 0.545 | 732 | 691 | 730 | 731 | 380 | 446 | 410 | 523 | 20315 | NM_013655 | Chemokine (C-X-C motif) ligand 12 |
Hbegf | 0.564 | 20,479 | 11,774 | 20,479 | 20,479 | 10,103 | 9,102 | 12,227 | 13,205 | 15200 | NM_010415 | Heparin-binding EGF-like growth factor |
Adm2 | 0.565 | 1,074 | 1,139 | 1,074 | 1,074 | 620 | 666 | 713 | 791 | 223780 | NM_182928 | Adrenomedullin 2 |
Serpine1 | 0.581 | 88,771 | 67,443 | 88,771 | 88,771 | 50,387 | 52,935 | 52,574 | 56,240 | 18787 | NM_008871 | Serine (or cysteine) peptidase inhibitor, clade E, member 1 |
Cyr61 | 0.598 | 32,600 | 27,400 | 32,600 | 32,600 | 20,205 | 18,159 | 21,347 | 23,270 | 16007 | NM_010516 | Cysteine rich protein 61 |
Loxl2 | 0.607 | 27,739 | 17,667 | 27,738 | 27,733 | 14,919 | 14,002 | 18,232 | 19,561 | 94352 | NM_033325 | Lysyl oxidase-like 2 |
Sox18 | 0.630 | 31 | 24 | 31 | 31 | 17 | 23 | 15 | 24 | 20672 | NM_009236 | SRY (sex determining region Y)-box 18 |
Angptl4 | 0.637 | 29,720 | 26,036 | 29,720 | 29,720 | 18,692 | 20,439 | 20,586 | 21,674 | 57875 | NM_020581 | Angiopoietin-like 4 |
Thbs1 | 0.638 | 418,163 | 252,972 | 418,164 | 418,164 | 234,104 | 246,596 | 267,973 | 289,271 | 21825 | NM_011580 | Thrombospondin 1 |
Shb | 0.647 | 850 | 619 | 850 | 850 | 472 | 425 | 659 | 713 | 230126 | NM_001033306 | Src homology 2 domain-containing transforming protein B |
Arhgap22 | 0.651 | 3,455 | 2,224 | 3,455 | 3,455 | 2,080 | 1,759 | 2,470 | 2,624 | 239027 | NM_153800 | Rho GTPase activating protein 22 |
Pgf | 0.657 | 978 | 531 | 978 | 979 | 384 | 529 | 712 | 860 | 18654 | NM_008827 | Placental growth factor |