Figure 1.

Figurative kinetics of adaptive and innate immune system response against SARS-CoV2 and disease evolution and outcome based on the degree of baseline thymopoiesis status. Left panels: baseline status for naïve T-cell output, peripheral TCR repertoire diversity, neo-antigen response, Treg-cells generation and monocyte cytokine production in patients with preserved (A) and impaired thymopoiesis and comorbidities due to ageing (B). Multiple degrees of variability can be included from A to B status. Right panels: temporal evolution for viral load, cytokine storm, type-I-IFN response, NK-lymphocyte levels, Treg cells, CTL and antibody level following exposure to SARS-CoV2 infection. Likely disease outcome is also indicated. IFN: interferon. Treg: regulatory T-cell. NK lymphocyte: Natural Killer lymphocyte. CTL: cytotoxic T lymphocyte. TCR: T-cell receptor.