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. 2020 Aug 5;28(2):1167–1177. doi: 10.1245/s10434-020-08926-4

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Small bowel adenocarcinoma (SBA) histologic subtypes (hematoxylin and eosin). a A glandular-type SBA, exhibiting well-formed glandular structures (original magnification × 200). b A medullary-type SBA, showing a solid pattern and a pushing border. As seen in the inset (MLH1 immunohistochemistry), tumor cells lacked nuclear expression of MLH1, which was retained in stromal and inflammatory cells (original magnification × 20, original magnification of inset × 200). c A mixed-type SBA, showing a combination of both glandular structures (on the left) and poorly cohesive cells (on the right), dispersed in a desmoplastic stroma (original magnification × 200). d A diffuse-type SBA, characterized by poorly cohesive, atypical cells in a desmoplastic stroma (original magnification × 200)