Table 2.
Relationship between mismatch repair status and clinicopathologic features in the 66 stage II small bowel adenocarcinomas
| MMR-d | MMR-p | P value | |
|---|---|---|---|
| Number of cases (%) | 28 (42) | 38 (58) | |
| Age at SBA diagnosis, years, mean ± SD | 60.1 ± 16.7 | 61.7 ± 12.9 | 0.659 |
| Sex, N (%) | 0.797 | ||
| Female | 11 (39) | 13 (34) | |
| Male | 17 (61) | 25 (66) | |
| Predisposing condition, N (%) | < 0.001 | ||
| Celiac disease | 16 (57) | 5 (13) | |
| Crohn’s disease | 3 (11) | 17 (45) | |
| Lynch syndromea | 7 (25) | 0 (0) | |
| None (sporadic) | 2 (7) | 16 (42) | |
| Site, N (%) | 1.000 | ||
| Duodenum | 2 (7) | 3 (8) | |
| Jejunum/ileum | 26 (93) | 35 (92) | |
| T level, N (%) | 0.576 | ||
| T3 | 22 (79) | 27 (71) | |
| T4 | 6 (21) | 11 (29) | |
| R status, N (%) | 0.035 | ||
| R0 | 28 (100) | 32 (84) | |
| R1 | 0 (0) | 6 (16) | |
| Adequate number of LN, N (%) | 1.000 | ||
| Yes | 16 (57) | 21 (55) | |
| No | 12 (43) | 17 (45) | |
| Any high-risk features, N (%) | 0.609 | ||
| No | 12 (43) | 13 (34) | |
| Yes | 16 (57) | 25 (66) | |
| Vascular or perineural invasion, N (%) | 0.456 | ||
| No | 15 (54) | 16 (42) | |
| Yes | 13 (46) | 22 (58) | |
| Histologic grade, N (%) | 0.300 | ||
| Low (G1–G2) | 16 (57) | 27 (71) | |
| High (G3) | 12 (43) | 11 (29) | |
| Any extended high-risk features, N (%) | 0.555 | ||
| No | 7 (25) | 7 (18) | |
| Yes | 21 (75) | 31 (82) | |
| Histologic subtype, N (%) | < 0.001 | ||
| Medullary | 5 (18) | 0 (0) | |
| Glandular | 23 (82) | 26 (68) | |
| Diffuse | 0 (0) | 6 (16) | |
| Mixed | 0 (0) | 6 (16) | |
| Histologic subtype group, N (%) | 0.001 | ||
| Cohesive | 28 (100) | 26 (68) | |
| Non-cohesive | 0 | 12 (32) |
LN lymph nodes; MMR-d mismatch repair deficient; MMR-p mismatch repair proficient; SBA small bowel adenocarcinoma; SD standard deviation
aIncluding 1 genetically confirmed Lynch syndrome patient and 6 cases strongly suspected for Lynch syndrome due to their histomolecular profiles