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. 2020 Jul 7;197(1):19–26. doi: 10.1007/s00066-020-01654-4

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© The Author(s) 2020

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Fig. 3 — Apparent diffusion coefficient (ADC) determined by diffusion-weighted magnetic resonance imaging before neoadjuvant treatment of pancreatic adenocarcinoma, after 2 days of the first cycle of chemotherapy, after two cycles of chemotherapy and after completion of neoadjuvant radiochemotherapy, error bar and individual line diagram of the ADC. a ADC at screening; mean ± standard deviation (SD): 1.32 ± 0.20 (95% confidence interval [CI]: 1.23–1.43); ADC at day 2 after first application of chemotherapy (gem/ox); mean ± SD: 1.30 ± 0.22 (95% CI: 1.19–1.41); ADC after completion of chemotherapy (CTx); mean ± SD: 1.32 ± 0.21 (95% CI: 1.21–1.44); ADC after completion of radiochemotherapy (RCTx); mean ± SD:1.43 ± 0.27 (95% CI: 1.26–1.59); p = 0.468 (one-way analysis of variance). b ADC in individual patients with highly variable response during the course of the study. The mean ADC did not show a distinct change in diffusion restriction