Table 1.
Baseline characteristics
| All patients | No HAIP | HAIP | p value | |
|---|---|---|---|---|
| Total | 374 | 293 | 81 | – |
| Patient characteristics | ||||
| Gender | 0.005 | |||
| Male | 235 | 195 (66.6%) | 40 (49.4%) | |
| Female | 139 | 98 (33.4%) | 41 (50.6%) | |
| Center | – | |||
| Erasmus MC | 143 (38.8%) | 143 (49.8%) | – | |
| MSKCC | 231 (61.2%) | 150 (51.2%) | 81 (100%) | |
| Colorectal cancer | ||||
| Primary tumor location | 0.24 | |||
| Right-sided | 78 (21.4%) | 56 (19.6%) | 22 (27.8%) | |
| Left-sided | 175 (48.1%) | 138 (48.4%) | 37 (46.8%) | |
| Rectum | 111 (30.5%) | 91 (31.9%) | 20 (25.3%) | |
| Missing | 10 | |||
| Pathologic T-stage | 0.09 | |||
| T1–T2 | 57 (16.4%) | 50 (18.1%) | 7 (9.7%) | |
| T3–T4 | 291 (83.6%) | 226 (81.9%) | 65 (90.3%) | |
| Missing | 26 | |||
| Primary tumor node status | 0.003 | |||
| N0 | 146 (40.1%) | 126 (44.1%) | 20 (25.6%) | |
| N+ | 218 (59.9%) | 160 (55.9%) | 58 (74.4%) | |
| Missing | 10 | |||
| Index CRLM | ||||
| Age at resection (median, IQR) | 61 (53–69) | 63 (56–70) | 54 (46–63) | < 0.001 |
| < 70 years | 295 (78.9%) | 219 (74.7%) | 76 (93.8%) | |
| ≥ 70 years | 79 (21.1%) | 74 (25.3%) | 5 (6.2%) | |
| Disease-free interval | 0.14 | |||
| ≤ 12 months | 77 (20.6%) | 65 (22.3%) | 12 (14.8%) | |
| > 12 months |
296 (79.4%) 1 |
227(77.7%) | 69 (85.2%) | |
| Number of CRLM | 0.48 | |||
| 1 | 150 (41.4%) | 120 (42.4%) | 30 (38.0%) | |
| > 1 | 212 (58.6%) | 163 (57.6%) | 49 (62.0%) | |
| Missing | 12 | |||
| Size of largest CRLM | 0.08 | |||
| ≤ 5 cm | 296 (88.4%) | 230 (86.6%) | 66 (94.3%) | |
| > 5 cm | 39 (11.6%) | 35 (13.4%) | 4 (5.7%) | |
| Missing | 39 | |||
| Preoperative CEA | 0.61 | |||
| ≤ 200 µg/l | 281 (91.2%) | 228 (90.8%) | 53 (93.0%) | |
| > 200 µg/l | 27 (8.8%) | 23 (9.2%) | 4 (7.0%) | |
| Missing | 66 | |||
| Clinical risk score | 0.09 | |||
| Low risk (0–2) | 184 (56.8%) | 152 (59.1%) | 32 (47.8%) | |
| High risk (3–5) | 140 (43.2%) | 105 (40.9%) | 35 (52.2%) | |
| Missing | 50 | |||
| Positive resection margin | 0.15 | |||
| Yes | 46 (12.8%) | 38 (13.5%) | 7 (9.2%) | |
| No | 294 (81.9%) | 231 (82.2%) | 62 (81.6%) | |
| RFA | 19 (5.3%) | 12 (4.3%) | 7 (9.2%) | |
| Missing | 15 | |||
| Ablation at time of resection | 0.46 | |||
| Yes | 90 (24.1%) | 73 (24.9%) | 17 (21.0%) | |
| No | 284 (75.9%) | 220 (75.1%) | 64 (79.0%) | |
| Perioperative SYS | < 0.001 | |||
| Yes | 277 (77.3%) | 203 (69.3%) | 74 (92.5%) | |
| No | 96 (25.7%) | 90 (30.7%) | 6 (7.5%) | |
| Missing | 1 |
CEA carcinoembryonic antigen, CRLM colorectal liver metastases, Erasmus MC Erasmus Medical Center, MSKCC Memorial Sloan Kettering Cancer Center, SYS systemic chemotherapy