Table 1.
Gene set enriched in human AML sample after chemotherapy.
| Gene Set name | FDR q-value |
|---|---|
| HALLMARK_UV_RESPONSE_DN | 1.31E−06 |
| HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION | 7.38E−05 |
| HALLMARK_IL2_STAT5_SIGNALING | 7.38E−05 |
| HALLMARK_COAGULATION | 7.93E−05 |
| HALLMARK_PROTEIN_SECRETION | 1.61E−04 |
| HALLMARK_ANDROGEN_RESPONSE | 2.56E−03 |
| HALLMARK_APICAL_JUNCTION | 2.56E−03 |
| HALLMARK_COMPLEMENT | 2.56E−03 |
| HALLMARK_KRAS_SIGNALING_UP | 2.56E−03 |
| HALLMARK_MTORC1_SIGNALING | 2.56E−03 |
| HALLMARK_APOPTOSIS | 8.77E−03 |
| HALLMARK_MITOTIC_SPINDLE | 1.62E−02 |
| HALLMARK_XENOBIOTIC_METABOLISM | 1.62E−02 |
| HALLMARK_TGF_BETA_SIGNALING | 4.78E−02 |
Gene set overlap analysis of the gene set highly expressed in human AML samples described by Hackl et al.32 with Hallmarks gene sets from MsigDB was performed.
Entries related to mTORC1 signal are highlighted in bold.