Fig. 1. LPS induces dynamically intestinal injury in piglets.

A Jejunal morphological characteristics (hematoxylin and eosin-stained). Arrows indicate lifting of epithelium at the tip of the villus, and villous atrophy. Circles indicate hemorrhage in the lamina propria. Original magnification: 100×, scale bars = 82.3 μm. B, C Jejunal villus height and crypt depth. D Serum D-lactate level. E Serum intestinal fatty acid binding protein (I-FABP) level. The pigs in control group were sacrificed at 0 h after injection with NaCl solution. The pigs in LPS groups were injected with LPS at 100 μg/kg body weight, and then were killed at 1, 2, 4, 8, 12, or 24 h after LPS challenge. Values are means ± SE, n = 6. ***p < 0.001, **p < 0.01 and *p < 0.05, significantly different from the control group (0 h).