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. 2021 Jan 11;12(1):62. doi: 10.1038/s41419-020-03365-1

Fig. 6. Inhibition of necroptosis by Nec-1 protects from intestinal injury in LPS-challenged piglets.

Fig. 6

A Jejunal morphological characteristics (haematoxylin and eosin stained). Arrows indicate lifting of epithelium at the tip of the villus, and villous atrophy. Circles indicate hemorrhage in the lamina propria. Original magnification: ×100, scale bars = 82.3 μm. B, C Jejunal villus height and crypt depth. D Serum D-lactate level. E Serum intestinal fatty acid-binding protein (I-FABP) level. The pigs were pretreated intraperitoneally with Nec-1 at 1.0 mg/kg body weight or equal volume of 2% DMSO solution 30 min before the intraperitoneal injection of LPS or saline, and the pigs were sacrificed at 4 h after LPS or saline injection. Values are means ± SE, n = 7. abcMeans without a common letter differ, p < 0.05.