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. 2021 Jan 11;12:264. doi: 10.1038/s41467-020-20465-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a, b In vivo prophylactic efficacy (a) and therapeutic efficacy (b) of MAb 2H2, c2H2, and/or the c2H2/c3C1 cocktail against SARS-CoV-2 infection. Upper left panel: study outline. Upper right panel: qRT-PCR analysis of viral RNA copies present in lung tissues after 3 days of infection. Lower panel: H&E staining of lung tissue sections at 3 d.p.i. For a, qPCR results are shown as fold increase relative to wide-type Balb/c group (without Ad5-hACE2 treatment). For b, qPCR results are expressed as viral RNA levels in different antibody treatment groups relative to that in the PBS control group. For top right panels in a and b, each symbol represents one mouse. Error bars represent SEM. Statistical significance was determined by a two-tailed Student’s t test and indicated as follows: ns not significant; *p < 0.05; **p < 0.01. For a, p value between the control group and the PBS group (Ad-hACE2 transduction) is 0.0073; p value between the PBS group and the 2H2 group is 0.0169. For early treatment experiment in b, p value between the PBS group and the 2H2 group is 0.0488; p value between the PBS group and the c2H2/c3C1 group is 0.0418. For delayed treatment experiment in b, p value between the PBS group and the c2H2 group is 0.0183; p value between the PBS group and the c2H2/c3C1 group is 0.0205; p value between the c2H2 group and the c2H2/c3C1 group is 0.7803.