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. 2021 Jan 11;11:385. doi: 10.1038/s41598-020-79603-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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An ER signaling pathway network identified by IMPALA using Symmans data. Gene colors represent the log2 fold change of gene expression between ‘early recurrence’ and ‘late recurrence’ patients in the Symmans dataset (red: over-expressed in ‘early recurrence’ group; green: over-expressed in ‘late recurrence’ group). Gene size is proportional to the probability (sampling frequency) estimated by GIST.