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. 2021 Jan 11;11:385. doi: 10.1038/s41598-020-79603-5

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cell line validation for identified pathway genes from patient datasets. The left panel shows the average log₂ expression of selected pathway genes. The right panel shows the log₂ expression of two cell line studies: (MCF7-STRP vs. MCF7RR-STRP and LCC1 vs. LCC2). Seven genes (IRS1, IRS2, IGF1R, TSC2, JUN, FOS, STAT3) are consistently over-expressed in the ‘early recurrence’ patient samples and sensitive human breast cancer cell lines. The remaining genes, which mainly relate to cell cycle and apoptosis, are over-expressed in the resistant groups.