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. 2021 Jan 11;11:430. doi: 10.1038/s41598-020-79948-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Lipid metabolism is differentially regulated in PAI-1 heterozygosity. RNA-SEQ was performed on hepatic mRNA from 20 week-old Pai-1^+/− and littermate WT control C57BL/6 J male mice fed SC (n = 3). (A) Hierarchical clustering of expression changes seen by RNA-seq. Heat map created using Morpheus (https://software.broadinstitute.org/morpheus/). (B) Volcano plot representation of all gene expression changes. Blue points represent statistically significant changes and red points represent non-significant changes. (C) Gene ontology analysis of statistical differentially expressed genes. Data generated using Metascape (https://metascape.org/gp/index.html#/main/step1). (D) Murine PCSK9 plasma levels. (E) Total cholesterol plasma levels. Values are express as mean ± SEM (n = 7).