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. 2021 Jan 11;11:430. doi: 10.1038/s41598-020-79948-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Long-term TM5614 treatment leads to a reduction in circulatory cholesterol and PCSK9 in mice fed a HFHS diet. WT C57BL/6 J male mice fed HFHS diet with and without TM5614. (A) Active PAI-1 levels (ng/mL). (B) Cholesterol distribution on plasma lipoprotein fractions resolved by FPLC from pooled samples (n = 2 for HFHS, n = 3 for HFHS + TM5614) (2-way ANOVA p = 0.03). (C) Quantification of cholesterol in each lipoprotein fraction calculated using area under the curve from the FPLC profile. (D) Hepatic mRNA expression of cholesterol regulatory pathway nodes. (E) Plasma PCSK9 levels (ng/mL). (F) LDLR protein levels from liver lysates (ng LDLR/mg Liver Protein). Values are express as mean ± SEM (n = 7), * p < 0.05, ** p < 0.01, *** p < 0.001.